Mitochondrial-derived peptide8 min read

MOTS-c: What It Is and the Research

A neutral, source-cited overview of MOTS-c for qualified and independent researchers — what it is, the areas the published literature has studied, and where to find the primary sources.

VNG Research TeamJuly 15, 2026
Class
Mitochondrial-derived peptide
Published studies cited
10
Literature span
2015–2024

For research & educational purposes only. This article is a neutral, procedural reference for laboratory / in-vitro research handling — not medical advice or a usage recommendation. These materials are not for human or animal consumption.

On this page

What MOTS-c is

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome. It is supplied as an analytical-grade reference material for laboratory research.

What the research has examined

Published research has investigated MOTS-c in metabolic-regulation and cellular-stress-response contexts, largely in animal and cell models.

Listing an area of study is not a claim about any product or outcome. These references are provided so qualified researchers can locate the primary literature. All materials are supplied for laboratory research use only.

Reconstitution reference

Standard laboratory reconstitution volumes for MOTS-c, from the VNG Reconstitution Sheet. See the full reconstitution guide for the method and concentration math.

ProductVialBacteriostatic waterResulting concentration
MOTS-c10 mg0.5 mL20 mg/mL
MOTS-c40 mg2 mL20 mg/mL

Published research

A selection of peer-reviewed and clinical literature indexed on PubMed. Provided so qualified researchers can locate the primary sources — inclusion here is not a claim about any product or outcome.

  1. Mechanistic studyMetabolites · 2023

    MOTS-c and metabolic disorders

    View on PubMed
  2. Mechanistic studyAmerican journal of physiology. Endocrinology and metabolism · 2021

    MOTS-c and muscle-atrophy signaling

    View on PubMed
  3. Mechanistic studyFrontiers in endocrinology · 2023

    MOTS-c mitochondrial peptide — therapeutic overview

    View on PubMed
  4. Mechanistic studyBioEssays : news and reviews in molecular, cellular and developmental biology · 2019

    MOTS-c as a mitochondrial regulator of the nucleus

    View on PubMed
  5. Mechanistic studyCell metabolism · 2015

    MOTS-c, metabolism & insulin resistance

    View on PubMed
  6. Mechanistic studyAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024

    MOTS-c and ovarian cancer — mechanism study

    View on PubMed
  7. Peer-reviewed studyMitochondrion · 2023

    MOTS-c and pulmonary fibrosis

    View on PubMed
  8. Mechanistic studyPharmacological research · 2022

    MOTS-c and gestational diabetes

    View on PubMed
  9. Mechanistic studyFrontiers in physiology · 2023

    MOTS-c and bone metabolism

    View on PubMed
  10. Human clinical studyInternational journal of molecular sciences · 2022

    MOTS-c in aging and age-related disease

    View on PubMed

References & resources

Related reference materials

VNG Research Team

VNG Labs supplies analytical-grade reference materials with lot-matched Certificates of Analysis. Our write-ups are neutral, source-cited references for qualified and independent researchers.

More from the research blog

Research use only. Not for human consumption or veterinary use. Sold exclusively to qualified researchers for in vitro and laboratory research. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Refrigerate upon receipt. Keep in dark environment.