alpha-MSH analog8 min read

Melanotan I: What It Is and the Research

A neutral, source-cited overview of Melanotan I for qualified and independent researchers — what it is, the areas the published literature has studied, and where to find the primary sources.

VNG Research TeamJuly 15, 2026
Class
alpha-MSH analog
Published studies cited
10
Literature span
2012–2024

For research & educational purposes only. This article is a neutral, procedural reference for laboratory / in-vitro research handling — not medical advice or a usage recommendation. These materials are not for human or animal consumption.

On this page

What Melanotan I is

Melanotan I (afamelanotide) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). It is supplied as an analytical-grade reference material for laboratory research.

What the research has examined

Published research has studied melanocortin analogs in the context of melanin/pigmentation biology and photoprotection models.

Listing an area of study is not a claim about any product or outcome. These references are provided so qualified researchers can locate the primary literature. All materials are supplied for laboratory research use only.

Reconstitution reference

Standard laboratory reconstitution volumes for Melanotan I, from the VNG Reconstitution Sheet. See the full reconstitution guide for the method and concentration math.

ProductVialBacteriostatic waterResulting concentration
Melanotan I10 mg2 mL5 mg/mL
Melanotan II10 mg2 mL5 mg/mL

Published research

A selection of peer-reviewed and clinical literature indexed on PubMed. Provided so qualified researchers can locate the primary sources — inclusion here is not a claim about any product or outcome.

  1. Peer-reviewed study · 2012

    Afamelanotide — overview

    View on PubMed
  2. Mechanistic studyNature reviews. Endocrinology · 2023

    Melanocortin system and metabolic disorders

    View on PubMed
  3. Peer-reviewed reviewPostepy dermatologii i alergologii · 2024

    Afamelanotide in skin disease — review

    View on PubMed
  4. Peer-reviewed studyArchives of dermatological research · 2019

    Acne pathogenesis and anti-acne agents

    View on PubMed
  5. Peer-reviewed studyExpert review of clinical pharmacology · 2021

    Afamelanotide and phototoxicity in protoporphyria

    View on PubMed
  6. Peer-reviewed reviewAmerican journal of clinical dermatology · 2016

    Afamelanotide in protoporphyria — review

    View on PubMed
  7. Peer-reviewed reviewJournal of drugs in dermatology : JDD · 2021

    Afamelanotide — dermatology applications review

    View on PubMed
  8. Peer-reviewed studyThe New England journal of medicine · 2015

    Afamelanotide for protoporphyria — NEJM

    View on PubMed
  9. Human clinical studyClinical pharmacokinetics · 2017

    Afamelanotide pharmacokinetics & clinical use

    View on PubMed
  10. Peer-reviewed studyExpert review of clinical pharmacology · 2015

    Afamelanotide and dermal phototoxicity

    View on PubMed

References & resources

Related reference materials

VNG Research Team

VNG Labs supplies analytical-grade reference materials with lot-matched Certificates of Analysis. Our write-ups are neutral, source-cited references for qualified and independent researchers.

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Research use only. Not for human consumption or veterinary use. Sold exclusively to qualified researchers for in vitro and laboratory research. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Refrigerate upon receipt. Keep in dark environment.